Top Definition
1.To be high on stimulants like Meth or coke.
2.To work obsessively or compulsively on something.
3.To adjust something.
4.To be way wrong about something
1.He did 4 fat ass lines, hes tweakin hard
2.I was tweakin on my room for like 4 hours
3.I was just Tweakin the carb on my truck
4.you think the Boston Celtics are the best team ever..man your tweakin.
লিখেছেন- Steve_Juggernaut 28 de এপ্রিল de 2006

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Outside of your normal boundaries
Boy 1: "Which came first the chicken or the egg?"
Boy 2: "Boi, what the.."
Boy 1: "My fault I'm tweakin"
লিখেছেন- Giddy 24 de এপ্রিল de 2005

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(v) To be high on amphetamine.
"We be tweakin, like every single weekend, we be tweekin."

"Last night I danced for 10 hours, I was tweakin hard."
লিখেছেন- saeed 20 de অক্টোবার de 2003

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1) to be high on stimulant supplements(vitamins) or drugs.

2) to be hyperactive.
1) sugar, caffeine, monster drinks, sugar, earl gray tea, amphetamine, methamphetamine are examples of commonly used stimulants that can cause a person to be tweakin. They can become fast-moving, jittery and if on meth violently jumpy or shaky (trembling)

2) ADD/ADHD, natural high, sugar high, caffeine high can cause tweakin (hypetactivity) where you'll just be all over t he place moving fast.

when someone is hyperactive it doesnt mean they are under the influence of methamphetamine where meth high causes similar behaviour but is a different kind of hyper.
লিখেছেন- skaterjack 6 de অক্টোবার de 2006

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Acting senseless or saying random things for no apparent reason or either under the influence of marijuana.
"Man, Janet is high and she tweakin' hard."
লিখেছেন- THA.ONE 30 de এপ্রিল de 2009

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Seeing Change Within Oneself, and achieving goals that will make their life better.

Doing Any kind of action that can make your life or someone else's life better.

Derives from the Company Tweaklife
If you gradually are doing better in school, your Tweakin'.

One do charitable work, your Tweakin' for making someone else's day better and helping them.
লিখেছেন- Head Tweaker' 28 de ফেব্রুয়ারি de 2011

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smoking meth
Dude he was tweakin' really bad
লিখেছেন- rollin_balls 24 de ফেব্রুয়ারি de 2009

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